![]() ![]() This suite is based upon the range of genetic mutations which drive HCC across the spectrum of human disease. To further understand these processes, we have developed a state-of-the-art suite of genetically engineered models of HCC, which mimic many key features of the human condition. ![]() ![]() We are also investigating how this same senescent state occurs during early cancer formation as an anti-cancer therapeutic target. We have described how these cells enter a state of shock, named senescence, in response to injury, and how preventing them from doing so can promote liver regeneration. These cells show immense regenerative capacity but are also the principle source of the most common primary liver cancer, hepatocellular carcinoma (HCC). My group has been interested in studying the regenerative responses to injury and aberrant proliferative responses in cancer of hepatocytes, the principle functional cell of the liver. ![]()
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